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The SSRIs are reported to cause sexual dysfunction in the following descending order of frequency: citalopram 72.7%; paroxetine 70.7%; sertraline 62.9%; fluvoxamine 62.3%; fluoxetine 57.7%.Weight gain Weight gain is another troubling side effect. Paroxetine, fluoxetine, citalopram and sertraline have been shown to increase body weight after 612 months of therapy.The SSRIs represent the first rationally designed class of psychotropic medications.

Citalopram has been associated with loss of libido and may be associated with a relatively higher level of sexual dysfunction compared with sertraline.

Lexapro is manufactured by Forest Pharmaceuticals, Inc. Neurotransmitters carry signals from one nerve cell to another.

Research suggests that abnormalities in neurotransmitter activity can affect mood and behavior.

Celexa (Citalopram) licensed indications: In January 2003, Prozac (fluoxetine) was approved by the FDA for the treatment of depression and OCD in children and adolescents who are 7 to 17 years of age.

Zoloft (Sertraline) licensed indications: Clinical trials comparing one SSRI with another indicate that drugs in this class are equally efficacious.

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